Condition: Epstein-Barr Virus Infection · Post-Transplant Lymphoproliferative Disorder · Sponsor: Daihong Liu
Epstein-Barr virus (EBV) DNAemia is a common and potentially serious complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and may progress to EBV-associated lymphoproliferative disorders. Current treatment options are limited, and effective immune-based therapies are still needed. This is an investigator-initiated, exploratory, open-label, single-arm clinical study designed to evaluate the safety, tolerability, and preliminary efficacy of EBV-specific T cell receptor-engineered T cells (EBV-TCR-T cell injection) in patients with EBV DNAemia after allo-HSCT. Eligible participants will receive intravenous infusions of EBV-TCR-T cells at escalating dose levels. Safety outcomes, EBV-DNA clearance, and preliminary efficacy will be assessed, along with pharmacokinetic and pharmacodynamic characteristics of the infused cells.
This description comes directly from the study's public registry record.
Daihong Liu · +8613681171597 · daihongrm@163.com
Liping Dou · +8613681207138 · lipingruirui@163.com
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| Chinese PLA General Hospital | Beijing, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07368634