Condition: Anterior Cruciate Ligament Injuries · Meniscus Tear · Sponsor: Imperial College London
This study will be conducted to see if a new Magnetic Resonance Imaging (MRI) scanner could give additional information or help view the body in a different way. The new scanner may be useful to diagnose conditions affecting tissues such as ligaments, tendons and cartilage more accurately, potentially improving the quality of care by the NHS. To develop such protocols and to test the clinical capabilities of the scanner, it is necessary to evaluate the scans of healthy volunteers before recruiting patient participants. Conventional MRI scans are unable to detect the signal from tissues such as ligaments, tendons, cartilage and cortical bone, which contain highly aligned collagen fibres and the signal decays too quickly to be captured. These tissues appear black and are only seen because of the surrounding brighter tissues. If a bright region appears, it can be a sign of an injury or disease, but it can also appear due to the Magic Angle artefacts, when the collagen fibres are at a specific angle to the main magnetic field of the MR scanner. This anomaly can make assessment of these tissues difficult. Currently the diagnostic gold standard is arthroscopy, though it is mostly undertaken therapeutically. The method harnesses this inherent tissue property to gain information about these collagen-rich tissues in joints. Using Magic Angle Direction Imaging (MADI) it is possible to obtain detailed information about the collagen fibre structures, and this is not available using con…
This description comes directly from the study's public registry record.
Chinmay Gupte, PhD · +44 (0) 20 331 21715 · chinmay.gupte@nhs.net
Karyn E Chappell, PhD · +44 (0) 20 7594 9212 · k.chappell@imperial.ac.uk
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| Imperial College London | London, United Kingdom | Recruiting |
| Imperial College NHS Trust, Department of Surgery and Cancer | London, United Kingdom | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07366619