Condition: Moderate to Severe Chronic Obstructive Pulmonary Disease · Sponsor: Pfizer
The purpose of this clinical trial is to learn about the effects and safety of the study medicine PF-07275315 for the potential treatment of COPD. COPD is a condition that makes it difficult to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 35 to 80 years old * Have had moderate-to-severe COPD for at least 12 months * Have a documented history of at least 2 moderate or severe exacerbations within the last 12 months * Have been continuously taking their regular maintenance treatment(s) for COPD over at least 6 months at a stable dose for 3 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 24 weeks for the Phase 2 part and 52 weeks for the Phase 3 part. We will compare the results of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants who will be involved in the Phase 2 part of the study for about 40 weeks. During this time, they will have 11 visits at the study clinic. Participants who will be involved in the Phase 3 part of the study for about 68 weeks. During this time, they will have 18 visits at the study clinic.
This description comes directly from the study's public registry record.
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| University of Alabama at Birmingham Lung Health Center | Birmingham, Alabama, United States | Recruiting |
| SEC Clinical Research | Dothan, Alabama, United States | Recruiting |
| Pulmonary Associates of Mobile, P.C. | Mobile, Alabama, United States | Recruiting |
| Chandler Clinical Trials | Chandler, Arizona, United States | Not Yet Recruiting |
| Pulmonary Associates, PA | Phoenix, Arizona, United States | Recruiting |
| IMAX Clinical Trials | La Palma, California, United States | Recruiting |
| NewportNativeMD, Inc. | Newport Beach, California, United States | Recruiting |
| California Medical Research Associates | Northridge, California, United States | Recruiting |
| Institute of HealthCare Assessment d/b/a Apex Clinical Research | San Diego, California, United States | Recruiting |
| Finlay Medical Research | Greenacres City, Florida, United States | Recruiting |
| Clinical Research Specialists LLC | Kissimmee, Florida, United States | Recruiting |
| Advanced Pulmonary Research Institute | Loxahatchee Groves, Florida, United States | Recruiting |
+ 91 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07363694