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Study identifier: NCT07361562 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Study of a Selective ERBB2 Inhibitor (CGT4255), in Patients With Advanced Solid Tumors

Condition: Advanced Solid Tumor, Adult · ERBB2 Altered Breast Cancer · ERBB2 Gene Amplification  ·  Sponsor: Cogent Biosciences, Inc.

PhasePhase 1
Planned participants100
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This is an open-label, phase 1/1b study evaluating the safety, tolerability, pharmacokinetic (what the body does to the drug), pharmacodynamic (what the drug does to the body), and antitumor activity of CGT4255 in adult participants with advanced solid tumors with ERBB2 alterations or HER2 overexpression.

This description comes directly from the study's public registry record.

Talk to the study team

Cogent Biosciences, Inc  ·  617-945-5576  ·  trialinfo@cogentbio.com

Always discuss trial participation with your own doctor first.

Locations (6)

START MidwestGrand Rapids, Michigan, United StatesRecruiting
NYU LangoneNew York, New York, United StatesRecruiting
Tennessee OncologyNashville, Tennessee, United StatesRecruiting
NEXT Oncology TexasAustin, Texas, United StatesRecruiting
START Mountain RegionWest Valley City, Utah, United StatesRecruiting
NEXT Oncology VirginiaFairfax, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07361562