Condition: Necrotizing Fascitis · Fournier Gangrene · Fournier's Gangrene · Sponsor: University of Cagliari
Necrotizing soft tissue infections (NSTIs) are rare but potentially life-threatening infections involving the skin and underlying tissues such as fat, fascia, and sometimes muscle. They can progress rapidly and, despite modern antibiotics, surgery, and intensive care, are still associated with high in-hospital mortality. A major challenge in the management of NSTIs is early diagnosis. Initial signs and symptoms are often nonspecific and may resemble less severe soft tissue infections, leading to diagnostic and therapeutic delays. Once identified, treatment requires urgent surgery, broad-spectrum antibiotics, and close monitoring, frequently in an intensive care setting. Even with appropriate treatment, the clinical course of NSTIs is highly variable. Some patients recover, while others develop severe complications such as septic shock or multiple organ failure and may die during hospitalization. Predicting outcomes early in the hospital stay remains difficult for clinicians. The aim of this observational study is to identify factors associated with in-hospital mortality in adult patients with NSTIs. In-hospital mortality, defined as death from any cause during the hospital stay for NSTI treatment, represents the most severe outcome and is of major relevance to patients and caregivers. The study focuses on clinical and laboratory data routinely available at hospital admission or during initial emergency department evaluation. These include patient demographics, vital signs…
This description comes directly from the study's public registry record.
Mauro Podda, MD, FACS, Professor of Surgery · +39 07051096571 · mauro.podda@unica.it
Valentina Murzi, MD · +39 07051096571 · valentina.murzi@unica.it
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| Cagliari University Hospital "Duilio Casula". | Cagliari, Italy | Recruiting |
| Niguarda Hospital, Trauma team. | Milan, Italy | Recruiting |
| San Gerardo Hospital, Department of Surgery | Monza, Italy | Recruiting |
| Gemelli Hospital, Rome. Department of Surgery. | Roma, Italy | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07359651