Condition: Respiratory Failure · Sponsor: University of Alberta
This protocol describes a randomized controlled feasibility vanguard study designed to investigate the implementation and effects of esophageal pressure-guided positive end-expiratory pressure (PEEP) titration in patients with high body mass index (BMI) mechanically ventilated patients at the Edmonton Zone. The study will enroll 30 patients with body mass index (BMI) \>=30 kg/m2 who require invasive mechanical ventilation, randomizing them in a 1:1 ratio to receive either esophageal pressure-guided PEEP titration or standard care management. The primary objective focuses on establishing the feasibility of conducting a larger definitive trial, while secondary objectives examine differences in applied PEEP levels, respiratory mechanics, and clinical outcomes between groups. The intervention protocol targets end-expiratory transpulmonary pressure of 0-2 cmH2O.
This description comes directly from the study's public registry record.
Fernando G Zampieri, MD · 780.492.9951 · fzampier@ualberta.ca
Caylin Chadwick, MSc · 780.492.9951 · Caylin.Chadwick@albertahealthservices.ca
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| University of Alberta Hospital | Edmonton, Alberta, Canada | Recruiting |
| Sturgeon Community Hospital | St. Albert, Alberta, Canada | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07359261