Condition: Infertility · Endometrial Peristalsis · Uterine Contraction · Sponsor: Mỹ Đức Hospital
The uterus is a dynamic muscular organ that undergoes rhythmic, wave-like contractions known as endometrial peristalsis or endometrial waves. This muscular activity, which is an essential component of natural fertility, presents a nuanced and sometimes contradictory role in the context of assisted reproductive treatments. Endometrial peristalsis refers to the frequency, amplitude, and pattern of myometrial contractions occurring in different reproductive phases. These peristalsis play vital roles in sperm transport, embryo migration, and implantation. Clinical and imaging studies suggest that abnormal patterns or excessive contractility at the time of embryo transfer may disrupt endometrial-embryo synchrony, impair implantation, and increase miscarriage risk. However, most evidence on endometrial peristalsis pertains to fresh embryo transfer cycles, natural conceptions, or pathological contexts, such as adenomyosis or fibroids, with limited insights regarding its effects on different endometrial preparation protocols in frozen embryo transfer (FET). Understanding the dynamics of endometrial peristalsis in this context is clinically important, as inappropriate contractile activity could physically expel the embryo or create a non-receptive environment, ultimately reducing the chances of live birth. Despite its theoretical significance, there is a paucity of robust, prospective data correlating endometrial peristalsis patterns measured around the time of FET with different endo…
This description comes directly from the study's public registry record.
Xuyen Thi Ha Le, MD · +84945260494 · bsxuyen.lth@myduchospital.vn
Tuong M Ho, MD · +84903633377 · tuongho.ivfmd@gmail.com
Always discuss trial participation with your own doctor first.
| My Duc Phu Nhuan Hospital | Ho Chi Minh City, Vietnam | Recruiting |
| IVFMD Phu Nhuan - My Duc Phu Nhuan Hospital | Ho Chi Minh City, Vietnam | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07358468