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Study identifier: NCT07357727 Synced from ClinicalTrials.gov · July 27, 2026
● Recruiting

A Phase 3 Study of Pelabresib (DAK539) and Ruxolitinib in Myelofibrosis (MF)

Condition: Primary Myelofibrosis (PMF) · Post-polycythemia Vera Myelofibrosis (PPV-MF) · Post-essential Thrombocythemia Myelofibrosis (PET-MF)  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 3
Planned participants460
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this trial is to evaluate whether treatment with pelabresib in combination with ruxolitinib leads to improved clinical outcomes compared to ruxolitinib alone in patients with primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF), or post-essential thrombocythemia myelofibrosis (PET-MF) who have not previously received Janus kinase (JAK) inhibitor therapy.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  1-888-669-6682  ·  novartis.email@novartis.com

Novartis Pharmaceuticals  ·  +41613241111  ·  novartis.email@novartis.com

Always discuss trial participation with your own doctor first.

Locations (30)

Summit Medical Group OncologyBerkeley Heights, New Jersey, United StatesRecruiting
The Ohio State University Comprehensive Cancer CenterColumbus, Ohio, United StatesRecruiting
Novartis Investigative SiteBuenos Aires, Buenos Aires F.D., ArgentinaRecruiting
Novartis Investigative SiteCapital Federal, ArgentinaRecruiting
Novartis Investigative SiteClayton, Victoria, AustraliaRecruiting
Novartis Investigative SiteHefei, Anhui, ChinaRecruiting
Novartis Investigative SiteGuangzhou, Guangdong, ChinaRecruiting
Novartis Investigative SiteNantong, Jiangsu, ChinaRecruiting
Novartis Investigative SiteYantai, Shandong, ChinaRecruiting
Novartis Investigative SiteWenzhou, Zhejiang, ChinaRecruiting
Novartis Investigative SiteBeijing, ChinaRecruiting
Novartis Investigative SiteChongqing, ChinaRecruiting

+ 18 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07357727