Condition: Classical Hodgkin Lymphoma · Sponsor: Assistance Publique - Hôpitaux de Paris
Classical Hodgkin lymphoma (cHL) accounts for 15% of all cases of cancer in children and adolescents and represents the first cause of cancer during adolescence. Combined multi-modal chemotherapy and modern radiation techniques have transformed cHL in a highly curable cancer. However, up to 10-15% of patients still experience recurrent or primary refractory disease. Thus, there is an unmet need for unravelling the underlying mechanisms of treatment failure and refractoriness in paediatric cHL. Further refinements of treatment strategy are still needed to improve treatment results both in relapse and refractory (R/R) patients and to reduce long-term morbidity and mortality treatment related. Therefore, two main objectives arise: to improve early detection of patients with a high relapse risk to potentially intensify the first line treatment and to better identify low risk patients to further reduce the treatment burden in this good-prognostic population. Initial disease stratification and long-term outcome predictions remain a challenging issue in the field. PET/CT is currently the reference imaging method for initial staging and improves detection of extra nodal disease. None of previous prognostic factors accurately identify patients who will respond adequately and therefore limit the ability to identify patients who should require treatment that is more intensive or new therapeutic approaches like immunotherapy. Taken together, these data emphasize a clear unmet need in the…
This description comes directly from the study's public registry record.
Mathieu SIMONIN, Medical Doctor · 00 33 1 44 73 66 04 · mathieu.simonin@aphp.fr
Fabrice JARDIN, Professor · + 33 1 49 28 23 06 · fabrice.jardin@chb.unicancer.fr
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| Pediatric Hematology and Oncology Department | Paris, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07356882