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Study identifier: NCT07355400 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Clinical Evaluation of the NeoPill Device for Reduction of Oral Bacterial Load in Patients With Fixed Orthodontic Appliances

Condition: Dental Plaque  ·  Sponsor: Neofunction d.o.o.

PhaseNA
Planned participants15
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersYes

About this study

This study evaluates the effectiveness of the NeoPill oral hygiene device in reducing oral bacterial load in adults wearing fixed orthodontic appliances. Maintaining oral hygiene is challenging for orthodontic patients due to limited access around brackets and wires, and current solutions often rely on chemical-based products and disposable tools. NeoPill is a reusable, battery-operated oral device designed to provide mechanical cleansing of the oral cavity. In this single-arm clinical evaluation, participants will undergo oral swab sampling before and immediately after a single 30-second application of the NeoPill device. The primary outcome is the change in aerobic bacterial load, measured as colony-forming units (CFUs), between pre- and post-treatment samples. Participants will also complete a short questionnaire to assess usability, comfort, and overall experience with the device. The study aims to generate preliminary clinical and user-experience data to support further development of the NeoPill device.

This description comes directly from the study's public registry record.

Talk to the study team

Georgina Kyriakoudes  ·  +35795112337  ·  aria@myaria.health

Constantinos Zamboglou  ·  00357 25208000  ·  validate@gmic-eu.com

Always discuss trial participation with your own doctor first.

Locations (1)

German Medical InstituteLimassol, CyprusRecruiting

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Source record: clinicaltrials.gov/study/NCT07355400