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Study identifier: NCT07353645 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

KRAS Neoantigen Nanovaccine as Adjuvant Therapy for Colorectal Cancer/Pancreatic Cancer

Condition: Colorectal Cancer · Pancreatic Cancer  ·  Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

PhasePhase 1/Phase 2
Planned participants49
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

This clinical trial will utilize a neoantigen nanovaccine constructed from the bacterial membranes of an engineered Lactococcus lactis strain (FOLactis). This platform, independently developed by our center, expresses KRAS antigenic peptides. The vaccine will be administered as adjuvant therapy to post-operative patients with colorectal or pancreatic cancer who carry KRAS mutations and are at high risk of recurrence. The study aims to assess the safety, immunogenicity, and preliminary efficacy of this neoantigen nanovaccine in a clinical setting.

This description comes directly from the study's public registry record.

Talk to the study team

Baorui Liu  ·  +86 025-83106666  ·  baoruiliu@nju.edu.cn

Always discuss trial participation with your own doctor first.

Locations (1)

Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing UniversityNanjing, Jiangsu, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07353645