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Study identifier: NCT07349537 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

Condition: Non-small Cell Lung Cancer (NSCLC) · Colorectal Cancer (CRC) · Pancreatic Adenocarcinoma  ·  Sponsor: Revolution Medicines, Inc.

PhasePhase 1
Planned participants574
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary antitumor activity of RMC-5127 as a monotherapy and in combination with either daraxonrasib or cetuximab in adults with KRAS G12V-mutant solid tumors.

This description comes directly from the study's public registry record.

Talk to the study team

Revolution Medicines Study Director  ·  1-844-2-REVMED  ·  medinfo@revmed.com

Always discuss trial participation with your own doctor first.

Locations (9)

Yale Cancer CenterNew Haven, Connecticut, United StatesRecruiting
Johns HopkinsBaltimore, Maryland, United StatesRecruiting
Dana-Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
START MidwestGrand Rapids, Michigan, United StatesRecruiting
Laura and Isaac Perlmutter Cancer Center at NYU Langone HealthNew York, New York, United StatesRecruiting
NEXT - DallasDallas, Texas, United StatesRecruiting
NEXTSan Antonio, Texas, United StatesRecruiting
START - San AntonioSan Antonio, Texas, United StatesRecruiting
NEXT - VirginiaFairfax, Virginia, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07349537