Condition: Sepsis · Septic Shock · Sponsor: Siriraj Hospital
The goal of this clinical trial is to determine whether early initiation of norepinephrine with rapid dose adjustment improves clinical outcomes in adult patients with septic shock. The study aims to evaluate the effect of early norepinephrine administration on mortality, hemodynamic stabilization, and resuscitation efficiency in adults aged 18 years and older diagnosed with septic shock. The main questions it aims to answer are: * Does early norepinephrine administration with rapid dose titration reduce 28-day mortality compared with standard treatment? * Does early norepinephrine administration with rapid dose tiration lead to faster shock control and reduced fluid requirements without increasing treatment-related adverse events? Researchers will compare early norepinephrine administration with rapid dose adjustment to placebo with standard sequential resuscitation and rescue norepinephrine as needed to see if early vasopressor initiation improves survival, shock resolution, and safety outcomes. Participants will: * Receive either norepinephrine or placebo infusion initiated within one hour of septic shock diagnosis, with dose adjustment every 15 minutes according to a standardized protocol * Undergo close hemodynamic and safety monitoring, including frequent vital sign assessment and limb perfusion evaluation * Receive standard sepsis care, including fluid resuscitation, antibiotics, and organ support as clinically indicated * Be followed for clinical outcomes and adv…
This description comes directly from the study's public registry record.
Titaporn Nasaarn, Medical Doctor · +66 82 429 5514 · menatitaporn@gmail.com
Chairat Permpikul, Professor · +66 81 408 1676 · chairat.per@mahidol.ac.th
Always discuss trial participation with your own doctor first.
| Faculty of Medicine Siriraj Hospital, Mahidol University | Bangkok Noi, Bangkok, Thailand | Recruiting |
| Kalasin Hospital | Kalasin, Changwat Kalasin, Thailand | Recruiting |
| Khon Kaen hospital | Khon Kaen, Changwat Khon Kaen, Thailand | Recruiting |
| Udon Thani Hospital | Udon Thani, Changwat Udon Thani, Thailand | Recruiting |
| Hatyai Hospital | Hat Yai, Hat Yai, Thailand | Recruiting |
| Maharaj Nakhon Si Thammarat Hospital | Nakhon Si Thammarat, ์Nakhon Si Thammarat, Thailand | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07343206