Condition: Hepatic Insufficiency · Cirrhosis, Liver · Sponsor: University Hospital, Strasbourg, France
Patients with hepatocellular insufficiency and/or cirrhosis are at risk of developing invasive fungal infections, particularly in critical care settings. In international recommendations, voriconazole is positioned as the first-line treatment for invasive aspergillosis. However, this molecule-and the azole class of antifungals-is associated with frequent hepatic toxicity. Available since 2018, isavuconazole appears to be better tolerated in patients without pre-existing liver dysfunction. The aim of this study is to retrospectively evaluate the validity of the hscore in intensive care and resuscitation patients.
This description comes directly from the study's public registry record.
Antonin HUGEROT, MD · 33 3 88 12 79 24 · antonin.hugerot@chru-strasbourg.fr
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| Médecine intensive - Réanimation - CHU de Strasbourg - France | Strasbourg, France | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07343037