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Study identifier: NCT07340190 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Drug-drug Interaction Study to Evaluate the Effects of Pelabresib on the Pharmacokinetics of Repaglinide, Midazolam, and Combined Oral Contraceptive in Patients With Advanced Malignancies

Condition: Advanced Malignancies  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 1
Planned participants24
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This drug-drug interaction (DDI) study aims to evaluate the impact of pelabresib at steady-state plasma concentrations on the pharmacokinetic (PK) profile of A) a single dose of repaglinide and a single dose of midazolam, and B) a single dose of combined drospirenone and ethinyl estradiol. The study will be conducted in adult participants with advanced malignancies for whom no standard or curative treatment options are available.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  +41613241111  ·  novartis.email@novartis.com

Novartis Pharmaceuticals  ·  novartis.email@novartis.com

Always discuss trial participation with your own doctor first.

Locations (5)

Novartis Investigative SiteCandiolo, TO, ItalyRecruiting
Novartis Investigative SitePozuelo de Alarcón, Madrid, SpainRecruiting
Novartis Investigative SiteBarcelona, SpainRecruiting
Novartis Investigative SiteMadrid, SpainRecruiting
Novartis Investigative SiteMadrid, SpainRecruiting

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Source record: clinicaltrials.gov/study/NCT07340190