Condition: Myocardial Injury After Noncardiac Surgery (MINS) · Postoperative Complications · Liver Neoplasm · Sponsor: Beijing Tsinghua Chang Gung Hospital
This multi-center, prospective observational study aims to develop and validate an interpretable prediction model for Myocardial Injury After Noncardiac Surgery (MINS) in patients undergoing major hepatobiliary surgery. The study adopts a nested modeling strategy, starting with baseline risk factors (e.g., RCRI) and stepwise incorporating hepatic inflow occlusion strategies (specifically comparing SPVO vs. Pringle maneuver) and routine intraoperative biomarkers. The model's performance will be evaluated using AUC, Net Reclassification Improvement (NRI), and Decision Curve Analysis (DCA), followed by interpretability analysis using SHAP values and external validation in an independent cohort.
This description comes directly from the study's public registry record.
Zhifeng Gao, MD · +86-15801249466 · gzfa02461@btch.edu.cn
Always discuss trial participation with your own doctor first.
| Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine，Tsinghua University | Beijing, China | Recruiting |
| Peking University International Hospital | Beijing, China | Recruiting |
| The First Affiliated Hospital of Army Medical University | Chongqing, China | Recruiting |
| Qingdao West Coast New Area People's Hospital | Qingdao, China | Recruiting |
| The First Affiliated Hospital of Shandong First Medical University | Shandong, China | Recruiting |
| Zhuhai People's Hospital | Zhuhai, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07335042