Condition: Relapsed Neuroblastoma · Sponsor: University of Birmingham
Neuroblastoma is one of the most common solid childhood tumours, and a major cause of cancer-related death in children. More than 1200 children/young adults a year are diagnosed in USA and Europe. Around 600 of these cases are considered high-risk, which means the cancer is more difficult to treat successfully. Despite improvements in survival over recent decades, a significant proportion of patients with high-risk neuroblastoma have disease that does not respond to standard treatments (refractory neuroblastoma) or comes back after completion of standard frontline treatment (relapsed neuroblastoma). Therefore, there is a need to develop new treatment strategies and test new drugs to improve outcomes for children with neuroblastoma. Aims Of The BEACON2 Trial * To improve survival for patients with relapsed neuroblastoma by developing new treatment combinations * To evaluate new treatment combinations in relapsed neuroblastoma, within a phase I/II trial that can impact clinical practice, while also allowing dose confirmation for new promising combinations * To evaluate the safety, activity, efficacy and impact on quality of life of these new treatment combinations in relapsed neuroblastoma patients * To improve our understanding of relapsed neuroblastoma biology and advance the development of targeted therapies using biomarkers, by conducting a comprehensive biomarker sample collection. Trial Design BEACON2 is a randomised phase I/phase II, open label, international trial. T…
This description comes directly from the study's public registry record.
Trial Coordinator · 44 (0) 121 4143799 · beacon2@trials.bham.ac.uk
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| Sydney Children's Hospital (SCH) | Sydney, Australia | Not Yet Recruiting |
| St. Anna Children´s Hospital | Vienna, Austria | Not Yet Recruiting |
| Cliniques Universitaires Saint-Luc (CUSL) | Brussels, Belgium | Not Yet Recruiting |
| Starship Children's Hospital (SSH) | Auckland, New Zealand | Not Yet Recruiting |
| Royal Aberdeen Children's Hospital | Aberdeen, United Kingdom | Recruiting |
| Royal Belfast Hospital for Sick Children | Belfast, United Kingdom | Not Yet Recruiting |
| Birmingham Children's Hospital | Birmingham, United Kingdom | Recruiting |
| Bristol Royal Hospital for Children | Bristol, United Kingdom | Recruiting |
| Addenbrookes Hospital | Cambridge, United Kingdom | Recruiting |
| Children's Hospital for Wales | Cardiff, United Kingdom | Recruiting |
| Royal Hospital for Sick Children | Edinburgh, United Kingdom | Not Yet Recruiting |
| Royal Hospital for Children | Glasgow, United Kingdom | Not Yet Recruiting |
+ 11 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07334301