Condition: Small Vessel Cerebrovascular Disease · Diabete Mellitus · Sponsor: University of Coimbra
Diet is established among the most relevant adjustable variables of human health in modern societies. The recognition by the World Health Organization of cognitive impairment and dementia associated with aging as one of the major public health challenges of our time, highlights the imperative need for a more comprehensive understanding of how different aspects of lifestyle, in particular diet, affect neural function and consequent cognitive performance throughout lifespan. The brain is endowed with fine mechanisms for a precise spatial and temporal control of cerebral blood flow (CBF) according to neural activity, the neurovascular coupling (NVC). Mounting evidence from preclinical and human studies demonstrate that NVC dysfunction is a key early factor contributing to the pathogenesis of cognitive decline and vascular cognitive impairment (VCI) in aging and conditions associated with accelerated microvascular aging, such as cerebral small vessel disease (cSVD). Failure at any part of the NVC pathway disrupts CBF resulting in catastrophic depletion of oxygenation and energy supply to brain cells, and, in the long run, to neuronal dysfunction and cognitive impairment. The investigators have shown that nitric oxide (NO) synthesized by neuronal nitric oxide synthase (nNOS) is a direct mediator of NVC and that decreased bioavailability of NO along aging compromised NVC and reduced local CBF. Shortly after the identification of nNOS as a source of NO for vasodilation in the brai…
This description comes directly from the study's public registry record.
Miguel Castelo Branco, MD PhD · +351 239488510 · mcbranco@fmed.uc.pt
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| Institute for Nuclear Sciences Applied to Health (ICNAS), University of Coimbra | Coimbra, Portugal | Recruiting |
| Unidade de Saúde Local de Coimbra (ULS Coimbra) | Coimbra, Portugal | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07329647