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Study identifier: NCT07328841 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Reduced-dose Versus Conventional-dose Intensity-modulated Radiation Therapy for Locally Advanced Nasopharyngeal Carcinoma With Remission After Induction Chemotherapy and Immunotherapy

Condition: Nasopharyngeal Carcinoma (NPC)  ·  Sponsor: Ming-Yuan Chen

PhasePhase 3
Planned participants456
Who can joinAll sexes, 18 Years to 70 Years
Healthy volunteersNo

About this study

To explore the efficacy and safety of reduced-dose radiotherapy combined with concurrent chemotherapy and immunotherapy in stage Ⅳa (AJCC 8th,) locally advanced nasopharyngeal carcinoma patients who are sensitive to induction chemoimmunotherapy (assessed as complete response \[CR\]/partial response \[PR\] by imaging, with EBV DNA copy number reduced to zero or below the lower limit of detection), so as to provide a new treatment option for these patients.

This description comes directly from the study's public registry record.

Talk to the study team

Ming-Yuan Chen, MD,PhD  ·  +86-20-87343361  ·  chenmy@sysucc.org.cn

Rui You, MD,PhD  ·  +86-13580439820  ·  your5@mail.sysu.edu.cn

Always discuss trial participation with your own doctor first.

Locations (12)

The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou, Guangdong, ChinaRecruiting
Cancer Center of Guangzhou Medical UniversityGuangzhou, Guangdong, ChinaRecruiting
Sun Yat-sen University cancer centerGuangzhou, Guangdong, ChinaRecruiting
The Second Affiliated Hospital of Sun Yat-sen University (SYSU)Guangzhou, Guangdong, ChinaRecruiting
Cancer Hospital of Shantou University Medical CollegeShantou, Guangdong, ChinaRecruiting
Zhongshan City People's HospitalZhongshan, Guangdong, ChinaRecruiting
The People's Hospital of Guangxi Zhuang Autonomous RegionNanning, Guangxi, ChinaRecruiting
Wuzhou Red Cross HospitalWuzhou, Guangxi, ChinaRecruiting
Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhan, Hubei, ChinaRecruiting
Central South University Cancer HospitalChangsha, Hunan, ChinaRecruiting
Xiangya Hospital of Central South UniversityChangsha, Hunan, ChinaRecruiting
The Fifth Affiliated Hospital of Sun Yat-sen UniversityGuangdong, Zhuhai, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07328841