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Study identifier: NCT07326709 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease

Condition: Huntington Disease  ·  Sponsor: Novartis Pharmaceuticals

PhasePhase 3
Planned participants770
Who can joinAll sexes, 21 Years to 70 Years
Healthy volunteersNo

About this study

The purpose is to assess safety and tolerability of votoplam and to determine whether votoplam slows disease progression in patients with early symptomatic Huntington's disease (HD) compared to the control arm. HTT227 - current compound code (former code is PTC518 from PTC Therapeutics), HTT227 is Novartis code under Novartis sponsorship.

This description comes directly from the study's public registry record.

Talk to the study team

Novartis Pharmaceuticals  ·  1-888-669-6682  ·  novartis.email@novartis.com

Novartis Pharmaceuticals  ·  +41613241111

Always discuss trial participation with your own doctor first.

Locations (41)

University of CA San DiegoLa Jolla, California, United StatesRecruiting
CenExcel Rocky Mtn Clin ResearchEnglewood, Colorado, United StatesRecruiting
Georgetown UniversityWashington D.C., District of Columbia, United StatesRecruiting
University Of South FloridaTampa, Florida, United StatesRecruiting
Parkinsons-Movement Disorder CtrChicago, Illinois, United StatesRecruiting
Indiana University HealthIndianapolis, Indiana, United StatesRecruiting
University of Iowa Health CareIowa City, Iowa, United StatesRecruiting
University of Kansas HospitalFairway, Kansas, United StatesRecruiting
Trinity Health MichiganGrand Rapids, Michigan, United StatesRecruiting
Albany Medical CollegeAlbany, New York, United StatesRecruiting
UBMD NeurologyBuffalo, New York, United StatesRecruiting
Columbia University Irving MedicalNew York, New York, United StatesRecruiting

+ 29 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07326709