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Study identifier: NCT07326566 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Study of Silevertinib With Temozolomide for the Treatment of Newly Diagnosed GBM With Unmethylated MGMT and EGFRvIII

Condition: Glioblastoma (GBM) · Newly Diagnosed Glioblastoma · GBM  ·  Sponsor: Black Diamond Therapeutics, Inc.

PhasePhase 2
Planned participants162
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The purpose of this study is to see if combining silevertinib with temozolomide after surgery and radiotherapy helps treat newly diagnosed glioblastoma (GBM) better than using temozolomide alone in the maintenance setting. Specifically, this study is being done to find answers to the following questions: * How much of the study drugs (silevertinib combined with temozolomide) should be given to participants with GBM? * What are the side effects participants have when taking the study drug (silevertinib combined with temozolomide)? * Can the study drug (silevertinib combined with temozolomide) help participants with GBM live longer without disease progression compared to treatment with temozolomide alone?

This description comes directly from the study's public registry record.

Talk to the study team

Black Diamond Therapeutics Clinical Trial Navigation Service  ·  (866) 955-4397  ·  blackdiamondtx@careboxhealth.com

Always discuss trial participation with your own doctor first.

Locations (22)

University of Alabama at Birmingham O'Neal Comprehensive Cancer CenterBirmingham, Alabama, United StatesRecruiting
Highlands Oncology GroupSpringdale, Arkansas, United StatesRecruiting
Cedars-Sinai Medical CenterLos Angeles, California, United StatesRecruiting
Yale Cancer CenterNew Haven, Connecticut, United StatesRecruiting
Johns Hopkins Sibley Memorial HospitalWashington D.C., District of Columbia, United StatesRecruiting
Miami Cancer InstituteMiami, Florida, United StatesRecruiting
Moffitt Cancer CenterTampa, Florida, United StatesRecruiting
Johns Hopkins Sidney Kimmel Cancer Center - BaltimoreBaltimore, Maryland, United StatesRecruiting
Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Beth Israel Deaconess Medical CenterBoston, Massachusetts, United StatesRecruiting
Dana Farber Cancer InstituteBoston, Massachusetts, United StatesRecruiting
Henry Ford Cancer- DetroitDetroit, Michigan, United StatesRecruiting

+ 10 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07326566