Condition: Adenoid Cystic Carcinoma · Sinonasal Carcinoma · Epirubicin · Sponsor: Eye & ENT Hospital of Fudan University
This study is for patients with locally advanced sinonasal adenoid cystic carcinoma (SNACC), a rare and challenging cancer that tends to invade nerves and the skull base. The research aims to test a new precise treatment strategy. First, all participants will receive three sessions of "interventional chemotherapy" (transarterial chemoembolization) with the drug Epirubicin, which delivers high-dose chemotherapy directly to the tumor to shrink it as much as possible. About 4-6 weeks after the third session, doctors will use MRI scans to evaluate how well the tumor responded. Based on this response, patients will follow one of two personalized treatment paths: those whose tumors did not completely disappear will undergo surgery followed by radiotherapy; those whose tumors show complete disappearance on imaging will receive precise radiotherapy alone, potentially avoiding major surgery. This is a prospective, multicenter study. The main goals are to evaluate the safety and effectiveness of this response-adapted strategy and to see if it can improve outcomes for patients with this difficult-to-treat cancer.
This description comes directly from the study's public registry record.
Quan Liu, M.D. · 86+15001959681 · liuqent@163.com
Wanpeng Li, M.D. · 86+13262856870 · 18879117831@163.com
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| Eye and ENT Hospital, Fudan University | Shanghai, Xuhui Strict, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07320508