Condition: Wild-type ATTR Amyloidosis · Amyloidosis Cardiac · Amyloidosis, Hereditary · Sponsor: University of Sao Paulo General Hospital
This study explores whether extracellular vesicles (EVs) tiny particles released into the bloodstream by cells can serve as early and minimally invasive biomarkers for transthyretin amyloid cardiomyopathy (ATTR-CM). Because ATTR-CM is often diagnosed only after significant heart damage has occurred, there is an urgent need for earlier detection methods. The study will enroll individuals with different clinical presentations of transthyretin amyloidosis, along with healthy controls. Participants will undergo blood sampling, cardiac imaging (including echocardiography, cardiac MRI, and scintigraphy when indicated), and molecular EV analysis. By comparing EV profiles across groups, the study aims to determine whether these vesicles reflect early cardiac involvement, track disease progression, and support more accurate and timely diagnosis. Ultimately, this research seeks to improve clinical decision-making and patient outcomes in ATTR cardiomyopathy.
This description comes directly from the study's public registry record.
Felix Jose A Ramires, MD, PhD · +551126615057 · felix.ramires@incor.usp.br
Camila R Moreno, PhD · 551126615201 · camila.moreno@hc.fm.usp.br
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| Instituto do Coracao, HCFMUSP | São Paulo, São Paulo, Brazil | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07314268