Condition: Tinea Corporis · Tinea Cruris · Sponsor: Abeer Mohamed Abdelaziz Elkholy
This pilot study will test intra-lesional immunotherapy (MMR vaccine) injections as a treatment for recalcitrant tinea cruris and corporis in patients aged 10-60 years who have not improved with standard antifungal treatments. \*Eligibility: Participants must have recalcitrant tinea, defined as: * Rapid progression or large areas of skin affected, * Infection in multiple family members, especially females and children * Rapid relapse after prior treatment * Suspected resistant T. indotineae (based on travel history or contact with affected individuals from high-prevalence regions) * Failure of at least 2 courses of systemic antifungal therapy in the past 3 months Treatment: Patients will receive intra-lesional MMR vaccine injections into the active borders of affected lesions every 2 weeks for up to 6 weeks. If partial improvement occurs but complete clearance is not achieved, the course may be repeated for another 6 weeks. Pulse itraconazole will be given during the first 2 weeks. Monitoring: At each study visit, clinicians will assess the extent of affected skin and monitor symptoms particularly itching. Safety will be closely observed, including injection-site reactions, fever, initial flare of lesions, and any rare serious allergic reactions. Goal: To evaluate the safety and effectiveness of intra-lesional MMR immunotherapy for patients with tinea that has been difficult to treat.
This description comes directly from the study's public registry record.
Abeer Mohamed Elkholy, MD degree of Dermatology · +201006210646 · abeerkholy@hotmail.com
Nora Mohamed Abdelrazik, MD degree of Dermatology · +201060291029 · noraeldarawany@gmail.com
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| Mansoura University Hospital | Al Mansurah, Dakahlia Governorate, Egypt | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07312604