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Study identifier: NCT07312227 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia

Condition: Hypertensive Disorder of Pregnancy · Pulmonary Arterial Hypertension · Intrauterine Growth Restriction  ·  Sponsor: Massachusetts General Hospital

PhaseN/A
Planned participants27
Who can joinFemale, 18 Years to 45 Years
Healthy volunteersYes

About this study

In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies residing at sea level, to characterize differences in cardiopulmonary adaptation and nitric oxide (NO) pathway expression at elevations \>3,500 m throughout pregnancy and into the postpartum period. The investigators aim to investigate right-sided cardiac impairment induced by chronic hypobaric hypoxemia, its effects on fetal growth, and the potential contribution of cardiovascular nitric oxide depletion to obstetric complications.

This description comes directly from the study's public registry record.

Talk to the study team

Lorenzo Berra, MD  ·  617-726-3030  ·  lberra@mgh.harvard.edu

Andrea Bolchini, MD  ·  617-216-5124  ·  abolchini@mgh.harvard.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Massachusetts General HospitalBoston, Massachusetts, United StatesRecruiting
Hospital De La MeujerLa Paz, BoliviaCompleted

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Source record: clinicaltrials.gov/study/NCT07312227