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Study identifier: NCT07310693 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

External Validation of the CLOVER Score for Detecting Occult Cancer in Venous Thromboembolism Patients

Condition: Venous Thromboembolism (VTE) · Occult Cancer  ·  Sponsor: Infanta Leonor University Hospital

PhaseN/A
Planned participants500
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

This study aims to externally validate the CLOVER score, a machine learning-based predictive model designed to identify patients with venous thromboembolism (VTE) who are at increased risk of having an occult cancer. The study includes a retrospective cohort of patients with acute symptomatic VTE diagnosed between 2000 and 2022, and a prospective cohort of consecutively recruited patients from December 2025 to December 2027. The CLOVER model will be applied to all participants, and its ability to discriminate between patients with and without occult cancer will be evaluated. The study also assesses clinicians' satisfaction with the web-based tool (CLOVER-Web) developed to facilitate the use of the score in clinical practice.

This description comes directly from the study's public registry record.

Talk to the study team

Anabel Franco Moreno, MD, PhD  ·  +34686102661  ·  afranco278@hotmail.com

Anabel Franco Moreno  ·  MD, PhD  ·  afranco278@hotmail.com

Always discuss trial participation with your own doctor first.

Locations (12)

Hospital ClínicBarcelona, Barcelona, SpainRecruiting
Hospital Universitario Infanta LeonorMadrid, Madrid, SpainRecruiting
Hospital Universitario La PazMadrid, Madrid, SpainRecruiting
Hospital Universitario Príncipe de AsturiasMadrid, Madrid, SpainRecruiting
Hospital Universitatio del SuresteMadrid, Madrid, SpainRecruiting
Hospital Universitario de MóstolesMadrid, Madrid, SpainRecruiting
Hospital Clínico Universitario Virgen de la ArrixacaMurcia, Murcia, SpainRecruiting
Hospital Universitario Morales MeseguerMurcia, Murcia, SpainRecruiting
Hospital San AgustínAvilés, Principality of Asturias, SpainRecruiting
Hospital Universitario Son LlatzerBalea, SpainRecruiting
Hospital Universitario 12 de OctubreMadrid, SpainRecruiting
Hospital Universitario de FuenlabradaMadrid, SpainRecruiting

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Source record: clinicaltrials.gov/study/NCT07310693