Condition: Residual Neuromuscular Block · Sponsor: Shanghai Pulmonary Hospital, Shanghai, China
Residual neuromuscular blockade (NMB) after general anesthesia increases the risk of postoperative respiratory complications (atelectasis, pneumonia, re-intubation) and delays pulmonary function recovery. Sugammadex, a γ-cyclodextrin that directly encapsulates rocuronium, reverses NMB rapidly and completely without cholinergic side effects, whereas neostigmine requires co-administration of an antimuscarinic and may leave residual blockade. In this multicenter, randomized, double-blind, controlled trial, 240 adult patients (ASA I-III) undergoing elective thoracoscopic lung resection (≤ 1 segment) will be randomized 1:1 to receive sugammadex (2 mg/kg) or neostigmine (0.03 mg/kg) + atropine (0.015 mg/kg) at the end of surgery. The primary endpoint is the percent decline in forced expiratory volume in 1 second (FEV₁) at 1 hour post-extubation compared to preoperative baseline; a ≥ 5% improvement with sugammadex is hypothesized. Secondary endpoints include FEV₁ at days 1-3, pain scores, opioid consumption, gastrointestinal recovery, quality of recovery (QoR-15), neuromuscular monitoring (TOF ratio), and incidence of postoperative pulmonary and surgical complications.
This description comes directly from the study's public registry record.
Shiyou Wei, PhD · 8615601680288 · lovewishyou@163.com
Xin Lv, PhD · 8618852869700 · xinlvg@126.com
Always discuss trial participation with your own doctor first.
| Shanghai Pulmonary Hospital | Shanghai, Shanghai Municipality, China | Recruiting |
| Shanghai East Hospital,Affiliated to Tongji University | Shanghai, Shanghai Municipality, China | Recruiting |
| Fudan university Shanghai cancer center | Shanghai, Shanghai Municipality, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07309393