Condition: Exercise · Sleep · Motor Learning · Sponsor: Zealand University Hospital
The ExSiMS study is a randomized, controlled crossover study including 20 individuals (18-70 years) diagnosed with relapsing remitting Multiple Sclerosis (MS) This project investigates, through behavioral and neurophysiological measurements, how aerobic exercise on an ergometer bike and sleep in the form of a nap and overnight sleep may enhance cortical motor skill learning evaluated by a complex hand motor skill test and thereby improve functional capacity in individuals with MS. Beyond the effect on motor skill learning, the project investigate the effect on electroencephalography (EEG) - electromyography (EMG) coherence. The study hypothesizes that individuals with neurological conditions, such as multiple sclerosis (MS), may experience beneficial effects on specific motor rehabilitation through systematically planned cardiovascular exercise and sleep scheduling, due to positive impacts on memory consolidation. Aims: * Investigate the brain's neurophysiological responses and memory effects following a training intervention and, separately, sleep, in the form of a power nap, in individuals with MS. * Examine whether these effects persist beyond the few days previously observed in healthy individuals by implementing a longer-term intervention. * Explore whether the training effect is influenced by disease activity in the brain, such as during relapses and during immunosuppressive treatment. * Assess whether the presence of abnormally reduced cognitive endurance (fatigue) …
This description comes directly from the study's public registry record.
Caroline Sadolin Muushardt, MSc · +45 46323200 · cmuu@regionsjaelland.dk
Martin Ballegaard, MD MPG PhD · mbag@regionsjaelland.dk
Always discuss trial participation with your own doctor first.
| Section of Movement and Neuroscience, Department of Nutrition, Exercise, and Sports, University of Copenhagen | Copenhagen, Denmark | Not Yet Recruiting |
| Zealand University Hospital Roskilde | Roskilde, Denmark | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07304375