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Study identifier: NCT07302425 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

High-intensity Resistance Training in Post-exacerbation COPD

Condition: COPD Exacerbation  ·  Sponsor: Istituti Clinici Scientifici Maugeri SpA

PhaseNA
Planned participants64
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

After a COPD exacerbation, many individuals experience severe weakness in the leg muscles, especially the quadriceps. This weakness can make daily activities difficult and slow down recovery. Traditional respiratory rehabilitation usually focuses on endurance training, which is effective but often hard to tolerate soon after an exacerbation due to persistent symptoms and limited functional capacity. This study aims to compare two early rehabilitation approaches during recovery from a COPD exacerbation: a maximal strength training (MST) programme using high loads and few repetitions, and a traditional endurance-based training programme. The investigators aim to determine whether MST is easier to tolerate, especially in terms of breathlessness, and whether MST can improve muscle strength, efficiency, and overall exercise tolerance as well as or better than endurance training. The results will help identify the most suitable rehabilitation strategy for individuals recovering from a COPD exacerbation, particularly for those who struggle with high-intensity endurance exercise.

This description comes directly from the study's public registry record.

Talk to the study team

Mara Paneroni, PhD, MSc  ·  +0039+030+8253  ·  mara.paneroni@icsmaugeri.it

Tiziana Bachetti, Pharm  ·  +0039+0382+593  ·  tiziana.bachetti@icsmaugeri.it

Always discuss trial participation with your own doctor first.

Locations (1)

ICS Maugeri IRCCS, Respiratory rehabilitation of the Institute of LumezzaneLumezzane, Brescia, ItalyRecruiting

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Source record: clinicaltrials.gov/study/NCT07302425