Condition: Hematologic Malignancy · Neutropenia · Bone Pain · Sponsor: Alexandria University
This is a comparative interventional study to determine the best way to prevent G-CSF induced bone pain in patients with hematological malignancies (blood cancers). G-CSF (Granulocyte Colony-Stimulating Factor) is a drug commonly used in these patients to boost white blood cell production, but it frequently causes severe bone pain. The study is comparing two oral medications for their effectiveness as a preventive treatment: * Diosmin-Hesperidin (a flavonoid supplement). * Loratadine (a common anti-allergy medication). The core question the study is trying to answer is: * Is diosmin-hesperidin effective in preventing G-CSF-induced bone pain compared to loratadine? * Does the combination of diosmin-hesperidin and loratadine offer better pain prevention than either drug alone?
This description comes directly from the study's public registry record.
Mayssaa Mohamed Elsayed, M.S. Candidate · +201097973834 · Maya_salam2007@yahoo.com
Noha AlaaEldine Hamdy, Assistant professor · Noha.alaaeldine@alexu.edu.eg
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| Alexandria University Hospitals | Alexandria, Egypt | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07300735