Condition: Syphilis · Sponsor: Monash University
How syphilis is transmitted between sexual partners is unclear. Asymptomatic detection i.e. detection of syphilis bacteria (Tp) from anatomical sites without lesions, in patients with syphilis infection, suggests that asymptomatic transmission from these sites may play a role. However, no existing studies have established whether the syphilis bacteria (Tp) detected was viable. This means it is not known if the bacteria at this anatomical site is alive and therefore able to transmit the infection. Further, studies have focused mostly on men who have sex with men, resulting in a lack of evidence regarding anal shedding in men-who-have-sex-with-women only and women (regardless of sexual behaviour), and no data on asymptomatic vaginal shedding in women. This study will explore: 1. Patterns of Tp detection in women and men-who-have-sex-with-women only. 2. Whether detected Tp from each asymptomatic anatomical sites is viable 3. Duration of Tp detection and viability (alive and transmissible bacteria). Patients presenting to a participating sexual health service (overseas only) for management of suspected/confirmed early infectious syphilis will be eligible. During the routine clinical examination, participants will have additional oral and anal swabs, urine, vaginal swab (where relevant), penile skin swab (where relevant) and blood sample collected, in addition to the routine samples taken from the same sites and routine serology collected when syphilis is diagnosed.
This description comes directly from the study's public registry record.
Brigid M Scally · +61399039300 · brigid.scally@monash.edu
Janet Towns · janet.towns@monash.edu
Always discuss trial participation with your own doctor first.
| Monash University | Melbourne, Victoria, Australia | Active Not Recruiting |
| Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine | Shanghai, Shanghai Municipality, China | Not Yet Recruiting |
| Shanghai Skin Disease Hospital | Shanghai, Shanghai Municipality, China | Not Yet Recruiting |
| National Institute for Communicable Diseases | Johannesburg, South Africa | Not Yet Recruiting |
| Foundation for Professional Development | Pretoria, South Africa | Not Yet Recruiting |
| Burrell Street Clinic, Guy's and St Thomas' | London, United Kingdom | Recruiting |
| Jefferiss Clinic St Mary's Hospital, Imperial College London | London, United Kingdom | Recruiting |
| Mortimer Market Centre | London, United Kingdom | Recruiting |
| London School of Hygiene & Tropical Medicine | London, United Kingdom | Active Not Recruiting |
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Source record: clinicaltrials.gov/study/NCT07300254