Condition: Stroke · Thrombolysis · DAPT(Dual Antiplatelet Therapy) · Sponsor: Sigmund Freud PrivatUniversitat
Rationale and Relevance: Branch Atheromatous Disease (BAD) describes an atherosclerotic occlusion of one of the deep penetrating cerebral arteries, including the lenticulostriate artery (LSA), paramedian pontine artery (PPA), and anterior choroidal artery (ACHA). BAD is frequently associated with early neurological deterioration (END), particularly progressive motor deficits that contribute to increased disability. Despite its clinical relevance, BAD remains underrepresented in major radiomorphological classification systems such as TOAST, which has led to limited evidence and unclear treatment strategies. Previous studies suggest that the efficacy of intravenous thrombolysis (IVT) may be reduced in BAD compared to other stroke etiologies. Objectives: The primary objective of this study is to evaluate the efficacy and safety of IVT compared with single antiplatelet therapy (SAPT) and dual antiplatelet therapy (DAPT) in patients with BAD-related stroke. A secondary objective is to examine the impact of acute-phase blood pressure fluctuations on END and functional neurological outcomes. Design and Methods: This international multicenter study will be conducted retrospectively according to the STROBE guidelines. Eligible patients include those with BAD-related stroke treated at one of the participating centers between 2010 and 2025. Inclusion criteria comprise characteristic diffusion-weighted MRI patterns in predefined vascular territories (LSA, PPA, ACHA) and a symptom on…
This description comes directly from the study's public registry record.
Julian Frederic Hotz, DDr. · +43 1 211210 · julian.hotz@meduniwien.ac.at
Marek Sykora, Prof. Dr. · +43 1 211210 · marek.sykora@bbwien.at
Always discuss trial participation with your own doctor first.
| Clinic Favoriten | Vienna, State of Vienna, Austria | Recruiting |
| Clinic Hietzing | Vienna, State of Vienna, Austria | Recruiting |
| Department of Neurology, St. John's Hospital, Vienna, Austria | Vienna, Austria | Recruiting |
| Department of Neurology, Medical University of Vienna | Vienna, Austria | Recruiting |
| Department of Neurology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin | Berlin, Germany | Not Yet Recruiting |
| Department of Neurology, Heidelberg University Hospital | Heidelberg, Germany | Recruiting |
| Department of Neurology & Stroke, University of Tübingen | Tübingen, Germany | Recruiting |
| Department of Neurology, Universityhospital of Bern | Bern, Switzerland | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07299994