Condition: Breast Cancer · Metastatic Breast Cancer · miRNAs · Sponsor: Atlas University
This prospective observational study aims to evaluate serum levels of PTEN, a tumor suppressor gene, and organ-specific microRNAs (miRNAs) associated with metastatic patterns in breast cancer. Serum samples will be analyzed using quantitative reverse transcription polymerase chain reaction (qRT-PCR)-based miRNA profiling and enzyme-linked immunosorbent assay (ELISA)-based PTEN quantification. Three groups will be included: patients with metastatic breast cancer (n=80), patients with non-metastatic early-stage breast cancer (n=40), and healthy controls (n=40). The primary objective is to identify serum biomarkers that differentiate metastatic from non-metastatic disease. Secondary analyses will evaluate correlations between biomarker levels and organ-specific metastatic involvement, including bone, lung, liver, and brain metastases. Findings from this study may support the development of a noninvasive serum-based tool for predicting metastatic patterns in breast cancer.
This description comes directly from the study's public registry record.
Emine Yildirim, MD · +905056234825 · opdreyildirim@gmail.com
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| Atlas University Faculty of Medicine | Istanbul, Istanbul, Turkey (Türkiye) | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07297134