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Study identifier: NCT07294950 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Impact of Semaglutide Withdrawal on Cardiometabolic Profile and Physiology of Energy Balance: Recovery Effects After Semaglutide Termination

Condition: Obesity (Disorder) · Weight Change · Blood Pressure Monitoring  ·  Sponsor: Mount Sinai Hospital, Canada

PhasePhase 3
Planned participants98
Who can joinAll sexes, 18 Years to 75 Years
Healthy volunteersNo

About this study

Semaglutide is a medication from the class of drugs called glucagon-like peptide-1 agonists that promote weight loss. There is little clinical data on the best strategy to achieve weight maintenance following weight reduction induced by semaglutide. For people who need to discontinue treatment, it is unknown whether the weight regain, its accompanied health benefits could be ameliorated with a gradual reduction in semaglutide. The investigators will study if a gradual reduction of semaglutide is associated with different heart risk profile and hormones involved in energy regulation as compared to immediate treatment cessation.

This description comes directly from the study's public registry record.

Talk to the study team

Caroline K Kramer, MD PhD  ·  +1 4165864800 ext 7628  ·  caroline.kramer@sinaihealth.ca

Always discuss trial participation with your own doctor first.

Locations (1)

Leadership Sinai Centre for DiabetesToronto, Ontario, CanadaRecruiting

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Source record: clinicaltrials.gov/study/NCT07294950