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Study identifier: NCT07294131 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Targeting Muscle Strength Loss Due to Hospitalization in Older Adults by Blood-flow Restriction Combined With an Electromyography-driven Serious Game.

Condition: Hospital Associated Disability · Immobility · Older Adults (65 Years and Older)  ·  Sponsor: Vrije Universiteit Brussel

PhasePhase 2
Planned participants120
Who can joinAll sexes, 65 Years to no upper limit
Healthy volunteersYes

About this study

This study investigates a new training method designed to help older adults preserve their muscle strength during hospitalization. When older adults are admitted to the hospital and spend long periods in bed, their muscles can weaken very quickly. This condition is known as hospital-associated disability (HAD), and it can lead to longer hospital stays, reduced independence, and an increased risk of complications or even death. Conventional strength training with heavy weights is often too demanding or unsafe for frail patients, especially just after surgery or illness. As a safer alternative, this study combines light muscle exercises with a medically validated technique called blood flow restriction (BFR), which gently reduces blood flow to the leg to boost the effects of light exercises. To make training more engaging and personalized, the GHOSTLY+ system was developed. This system consists of a game played on a tablet that responds to muscle activity through sensors placed on the skin. While playing, patients perform isometric muscle contractions (exercises where the muscles tighten without moving the joint) that help to maintain and rebuild strength. The system was carefully designed in collaboration with patients and therapists, and it has already been tested in a smaller pilot study at UZ Brussel. The current study is a multicenter randomized controlled trial, taking place at UZ Brussel, UZ Antwerpen, and UZ Leuven. A total of 120 patients aged 65 or older will be rec…

This description comes directly from the study's public registry record.

Talk to the study team

Eva Swinnen, prof. dr.  ·  +32 (0)2 477 45 27  ·  eva.swinnen@vub.be

Mahyar Firouzi, Dr.  ·  +32 472 55 47 56  ·  mahyar.firouzi@vub.be

Always discuss trial participation with your own doctor first.

Locations (3)

Universitair Ziekenhuis AntwerpenAntwerp, BelgiumNot Yet Recruiting
Universitair Ziekenhuis BrusselBrussels, BelgiumRecruiting
Universitair Ziekenhuis LeuvenLeuven, BelgiumRecruiting

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Source record: clinicaltrials.gov/study/NCT07294131