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Study identifier: NCT07293650 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

PREcision MEDicine In Achalasia (PREMEDIA)

Condition: Type I Achalasia · Type II Achalasia · EGJ Outflow Obstruction Without Spastic/Hypercontractile Features  ·  Sponsor: Northwestern University

PhasePhase 3
Planned participants372
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

The goal of this clinical trial is to learn if shorter Per-Oral Endoscopic Myotomy (POEM) works as well as a longer POEM in patients with trouble swallowing due to certain conditions. The main question\[s\] it aims to answer \[is/are\]: * Does making a smaller cut in the muscle at the bottom of the esophagus work just as well as making the standard bigger cut in relieving symptoms? * Does making the smaller cut reduce the side effects of the procedure compared to the standard bigger cut? Researchers will compare the symptoms and side effects of making a shorter cut to the symptoms and side effects of a longer cut. Participants will allow researchers to access their standard of care information in their medical record, complete questionnaires at up to 6 times over a 2-year period.

This description comes directly from the study's public registry record.

Talk to the study team

Elizabeth Yan, BS  ·  312-908-1723  ·  elizabeth.yan@northwestern.edu

Yasmin Pina, BS  ·  312-503-6459  ·  yasmin.pina@northwestern.edu

Always discuss trial participation with your own doctor first.

Locations (15)

Mayo Clinic ArizonaScottsdale, Arizona, United StatesNot Yet Recruiting
University of California San DiegoLa Jolla, California, United StatesNot Yet Recruiting
University of Colorado DenverDenver, Colorado, United StatesNot Yet Recruiting
University of FloridaGainesville, Florida, United StatesNot Yet Recruiting
Adventist Health System/Sunbelt, IncOrlando, Florida, United StatesNot Yet Recruiting
Emory UniversityAtlanta, Georgia, United StatesNot Yet Recruiting
Northwestern UniversityChicago, Illinois, United StatesRecruiting
Johns Hopkins UniversityBaltimore, Maryland, United StatesNot Yet Recruiting
Washington UniversitySt Louis, Missouri, United StatesNot Yet Recruiting
Weill Cornell Medical CollegeNew York, New York, United StatesNot Yet Recruiting
Atrium Health/Wake ForestCharlotte, North Carolina, United StatesRecruiting
Case Western Reserve UniversityCleveland, Ohio, United StatesNot Yet Recruiting

+ 3 more locations — full list on the registry record.

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Source record: clinicaltrials.gov/study/NCT07293650