Condition: Solid Organ Transplantation · Pregnancy · Long-term Follow-up · Sponsor: University Medical Center Groningen
Background Pregnancy after all types of solid organ transplantation (SOT) is possible, although these have higher risk of pregnancy complications for mother and child, such as preeclampsia and preterm birth. Thus, the development of the unborn child seems to be affected by the transplant and its consequences such as the immunosuppressive medication use. Worldwide data regarding follow-up after birth is scarce. The very limited existing data existing only in young children are reassuring. However, the investigators hypothesize that there are health risks for the children. Given the side effects of the immunosuppressive medication on patients and limited knowledge from animal studies, the investigators particularly expect cardiovascular effects such as hypertension and kidney damage. These develop over a long time-period and lead late to symptoms. Aims Aim of this study is to gain more insight into the overall health of offspring born after SOT. Primary aim is to assess the cardiovascular health and the presence of kidney disease, and compare these with reference values from the general population or birth cohorts. Secondary aims are the immunological status including the microbiome of the child given the maternal immunosuppressive medication use, and the overall development of the offspring, including qualitative research regarding the quality of life. Third aim is to assess if there are differences in health between offspring born to mothers with a kidney, liver, pancreas (i…
This description comes directly from the study's public registry record.
Margriet F.C. de Jong, MD, PhD, MBA · +31655256391 · m.f.c.de.jong@umcg.nl
Jildau R. Meinderts, MD · j.r.meinderts@umcg.nl
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| University Medical Center Groningen | Groningen, Provincie Groningen, Netherlands | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07291258