Condition: Esophageal Squamous Cell Carcinoma (ESCC) · Sponsor: Hebei Medical University Fourth Hospital
This study is a single-arm clinical trial to evaluate the efficacy and safety of Iparomlimab and Tuvonralimab combined with chemotherapy in the first-line treatment of patients with recurrent or metastatic esophageal squamous cell carcinoma (ESCC). After screening and meeting the inclusion criteria, the patients were enrolled and received 6 cycles of Iparomlimab and Tuvonralimab combined with albumin-bound paclitaxel and cisplatin. Subsequently, maintenance treatment was carried out using Iparomlimab and Tuvonralimab ± albumin-bound paclitaxel until disease progression or the occurrence of unacceptable adverse events, with a total maximum treatment duration of 24 months. The main objective of this study is to: 1. evaluate the ORR of Iparomlimab and Tuvonralimab combined with albumin-bound paclitaxel and cisplatin. 2. The secondary endpoints include PFS, DCR, DoR, OS and safety, etc.
This description comes directly from the study's public registry record.
Shengmian Li · +8613931185237 · shengmianli2013@163.com
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| Hebei Medical University Fourth Hospital | Shijiazhuang, Hebei, China | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07290010