Condition: Lung Non-Small Cell Carcinoma · Stage IIIB Lung Cancer AJCC v8 · Stage IV Lung Cancer AJCC v8 · Sponsor: City of Hope Medical Center
This phase II trial tests the impact of biomarkers in predicting initial treatment (first-line) PD1 or PD-L1 (PD\[L\]-1)-based immunotherapy response and in selecting second-line treatment in patients with stage IIIB-IV non-small cell lung cancer (NSCLC). Response and survival rates in advanced stage NSCLC, unlike other cancers, rely on response to first-line therapy. Immunotherapy with PD(L)1-based therapy, may induce changes in body's immune system and may interfere with the ability of tumor cells to grow and spread. While immunotherapy has improved survival rate, the prognosis remains poor with most patients receiving chemotherapy after immunotherapy. Many types of tumors tend to lose cells or release different types of cellular products including their deoxyribonucleic acid (DNA) which is referred to as circulating tumor DNA (ctDNA) into the bloodstream before changes can be seen on scans. Health care providers can measure the level of ctDNA in blood or other bodily fluids to determine which patients are at higher risk for disease progression or relapse. The first part of this trial, studying samples of blood and tissue in the laboratory from patients receiving immunotherapy may help doctors learn more about the effects PD(L)1-based therapy on cells. It may also help doctors understand how well patients respond to treatment and may help develop new individualized treatment strategies. The second part of this trial also tests the effect of second-line immunotherapy, such a…
This description comes directly from the study's public registry record.
Contact details are listed per location below or on the registry record.
Always discuss trial participation with your own doctor first.
| CTCA at Western Regional Medical Center | Goodyear, Arizona, United States | Recruiting |
| City of Hope Corona | Corona, California, United States | Recruiting |
| City of Hope Medical Center | Duarte, California, United States | Recruiting |
| City of Hope Seacliff | Huntington Beach, California, United States | Recruiting |
| City of Hope at Irvine Lennar | Irvine, California, United States | Recruiting |
| City of Hope Antelope Valley | Lancaster, California, United States | Recruiting |
| City of Hope at Long Beach Elm | Long Beach, California, United States | Recruiting |
| City of Hope at Newport Beach Fashion Island | Newport Beach, California, United States | Recruiting |
| City of Hope South Pasadena | South Pasadena, California, United States | Recruiting |
| City of Hope South Bay | Torrance, California, United States | Recruiting |
| City of Hope Upland | Upland, California, United States | Recruiting |
| City of Hope Atlanta Cancer Center | Newnan, Georgia, United States | Recruiting |
+ 1 more locations — full list on the registry record.
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT07288034