Condition: Lymphoma Diffuse Large B-cell · Leukemia and Lymphoma · Leukemia Relapse · Sponsor: AvenCell Therapeutics, Inc.
This study is testing Allo-QuadCAR01-T, a new off-the-shelf CAR-T therapy for people with hard-to-treat B-cell cancers. Unlike current CAR-T treatments that use a patient's own cells, this therapy uses donor cells that are ready to use, which can save time and reduce costs. It targets two proteins, CD19 and CD20, to lower the chance of relapse and uses gene editing to make it safer. The trial has three parts: first to find a safe dose, then to confirm it, and finally to test how well it works in patients with diffuse large B-cell lymphoma (DLBCL). Patients will get one infusion after chemotherapy to prepare their body. The main goal is to check safety and see how many patients have a complete response by Week 13. About 160 patients will take part, and researchers will follow them for up to 15 years.
This description comes directly from the study's public registry record.
Antje Warth, Dr. · 0493514466450 · avc-203-01@avencell.com
Markese Sanders · 617-941-7468 · avc-203-01@avencell.com
Always discuss trial participation with your own doctor first.
| University of Chicago | Chicago, Illinois, United States | Not Yet Recruiting |
| Northwestern University | Evanston, Illinois, United States | Not Yet Recruiting |
| Brown University Health | Providence, Rhode Island, United States | Not Yet Recruiting |
| Sarah Cannon Research Institute | Nashville, Tennessee, United States | Recruiting |
| MD Anderson Cancer Center | Houston, Texas, United States | Not Yet Recruiting |
| Universitätsklinikum Ulm | Ulm, Baden-Wurttemberg, Germany | Recruiting |
| Universitätsklinikum Erlangen | Erlangen, Bavaria, Germany | Recruiting |
| Klinikum der Universität München | Munich, Bavaria, Germany | Not Yet Recruiting |
| Universitätsklinikum Marburg | Marburg, Hesse, Germany | Not Yet Recruiting |
| Uniklinikum Erlangen | Essen, North Rhine-Westphalia, Germany | Not Yet Recruiting |
| Universitätsklinikum Dresden | Dresden, Saxony, Germany | Recruiting |
| Charité Universitätsmedizin Berlin | Berlin, Germany | Recruiting |
+ 1 more locations — full list on the registry record.
Get one email when the public record changes — results posted, or the study's status changes. Nothing else, ever.
We email about this public record only. Unsubscribe anytime with one click. Never medical advice.
This page is independently generated by Eichor from the public ClinicalTrials.gov record and re-synced daily. It is not the sponsor's official website unless claimed. Nothing here is medical advice; eligibility is always determined by the study team — talk to your own doctor first.
Source record: clinicaltrials.gov/study/NCT07284433