Condition: Advanced Gastric or Gastroesophageal Junction Adenocarcinoma · Sponsor: Shanghai Junshi Bioscience Co., Ltd.
This is a multicenter, randomized, controlled, open-label, Phase III study, designed to evaluate the efficacy and safety of JS107 versus investigator-selected therapy in the second-line or later treatment of patients with advanced gastric or gastroesophageal junction adenocarcinoma positive for CLDN18.2. The study population consists of patients with CLDN18.2-positive, HER2-negative, locally advanced or metastatic gastric or gastroesophageal junction adenocarcinoma who have received at least one prior line of systemic therapy. The primary endpoints of the study are BICR-assessed progression-free survival and overall survival. Number of subjects and allocation:This study plans to enroll approximately 560 subjects, who will be randomized in a 1:1 ratio to receive either JS107 (experimental group) or investigator-selected therapy (control group).
This description comes directly from the study's public registry record.
Yongdong Zhang · 18042483763 · yongdong_zhang@junshipharma.com
Always discuss trial participation with your own doctor first.
| AnHui Provincial Cancer Hospital | Hefei, Anhui, China | Not Yet Recruiting |
| Peking University First Hospital | Beijing, Beijing Municipality, China | Not Yet Recruiting |
| Beijing Friendship Hospital, Capital Medical University | Beijing, Beijing Municipality, China | Not Yet Recruiting |
| Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital | Fuzhou, Fujian, China | Not Yet Recruiting |
| Union Hospital Affiliated to Fujian Medical University | Fuzhou, Fujian, China | Not Yet Recruiting |
| The First Hospital of Lanzhou University | Lanzhou, Gansu, China | Not Yet Recruiting |
| Gansu Provincial Cancer Hospital | Lanzhou, Gansu, China | Not Yet Recruiting |
| Gansu wuwei tumor hospital | Wuwei, Gansu, China | Not Yet Recruiting |
| Sun Yat-sen University Cancer Center | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Nanfang hospital | Guangzhou, Guangdong, China | Not Yet Recruiting |
| The sixth affiliated hospital sun yat-sen university | Guangzhou, Guangdong, China | Not Yet Recruiting |
| Meizhou People's Hospital（Huangtang Hospital） | Meizhou, Guangdong, China | Not Yet Recruiting |
+ 56 more locations — full list on the registry record.
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Source record: clinicaltrials.gov/study/NCT07284134