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Study identifier: NCT07283770 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Dose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-581 in Healthy Participants

Condition: Cystic Fibrosis  ·  Sponsor: Vertex Pharmaceuticals Incorporated

PhasePhase 1
Planned participants136
Who can joinAll sexes, 18 Years to 55 Years
Healthy volunteersYes

About this study

The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of single dose of VX-581 and multiple ascending doses of VX-581 alone and in combination with tezacaftor (TEZ)/deutivacaftor (D-IVA) or D-IVA for up to ten days.

This description comes directly from the study's public registry record.

Talk to the study team

Medical Information  ·  617-341-6777  ·  medicalinfo@vrtx.com

Always discuss trial participation with your own doctor first.

Locations (1)

Altasciences - Kansas CityOverland Park, Kansas, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07283770