Condition: Cisplatin-related Hearing Loss · Sponsor: The Netherlands Cancer Institute
The goal of this clinical trial is to learn if transtympanic sodium thiosulfate (STS) injections can prevent hearing loss caused by cisplatin chemotherapy in adults with head and neck cancer. The main question it aims to answer is: Researchers will compare the ear treated with STS gel to the untreated ear within the same patient to see if STS prevents hearing loss. Participants will: 1. Receive STS gel injections into the middle ear of one ear (randomized) within 3 hours before each cisplatin infusion (3-7 injections per patient). 2. Undergo hearing tests at baseline and 2-4 months after the last cisplatin treatment. 3. Complete questionnaires about hearing and tinnitus at baseline and 2-4 months after treatment.
This description comes directly from the study's public registry record.
Daniël Griffioen, MD · +31205129111 · da.griffioen@nki.nl
Jeany Rademaker-Lakhai, PhD · 0205129111 · j.lakhai@nki.nl
Always discuss trial participation with your own doctor first.
| Antoni van Leeuwenhoek | Amsterdam, North Holland, Netherlands | Recruiting |
| Leiden University Medical Center | Leiden, South Holland, Netherlands | Recruiting |
| Erasmus Universitair Medisch Centrum Rotterdam | Rotterdam, South Holland, Netherlands | Not Yet Recruiting |
| University Medical Center Utrecht | Utrecht, Utrecht, Netherlands | Not Yet Recruiting |
| Stichting Radboud University Medical Center | Nijmegen, Netherlands | Not Yet Recruiting |
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Source record: clinicaltrials.gov/study/NCT07281508