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Study identifier: NCT07278557 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Sparing Parotid Ducts Via MRI Sialography for Reduced Patient-Reported Xerostomia

Condition: Head and Neck Cancer  ·  Sponsor: UNC Lineberger Comprehensive Cancer Center

PhasePhase 2
Planned participants98
Who can joinAll sexes, 18 Years to no upper limit
Healthy volunteersNo

About this study

Radiation-induced xerostomia (dry mouth) is one of the most common and severe side effects for patients receiving radiation therapy for head and neck cancer. New approaches are needed to reduce this side effect and improve patients' quality of life after treatment. This is a Phase II, single-center, double-masked, parallel-arm, randomized controlled trial. It compares MRI-guided parotid ductal sparing to the standard approach of mean parotid gland sparing, focusing on patient-reported dry mouth outcomes in individuals receiving definitive radiotherapy for oropharyngeal cancer.

This description comes directly from the study's public registry record.

Talk to the study team

Tuvara King  ·  (984) 974-0000  ·  tjking@med.unc.edu

Melissa Knutsen  ·  (984) 974-0000  ·  Melissa_Knutsen@med.unc.edu

Always discuss trial participation with your own doctor first.

Locations (1)

University of North Carolina at Chapel Hill, Department of Radiation OncologyChapel Hill, North Carolina, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07278557