Condition: Metastatic Uveal Melanoma · Sponsor: H. Lee Moffitt Cancer Center and Research Institute
This Phase 2 study evaluates the efficacy and safety of sequential treatment with percutaneous hepatic perfusion (PHP) using melphalan/HDS followed by tebentafusp in patients with metastatic uveal melanoma (mUM) with isolated liver metastases. The rationale is that PHP enhances antigen release and immunomodulation, potentially sensitizing tumors to tebentafusp in HLA-A\*02:01-positive patients.
This description comes directly from the study's public registry record.
Deanryan De Aquino · 813-745-3998 · Deanryan.Deaquino@moffitt.org
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| Moffitt Cancer Center | Tampa, Florida, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07276386