Condition: Platelet Aggregation · Kidney Transplant Rejection · Sponsor: University Hospital, Martin
The study titled "Platelet Aggregation in the Diagnosis of Acute Graft Rejection" is a pilot observational study evaluating whether alterations in platelet function can serve as non-invasive markers of acute rejection in kidney transplant recipients. Platelet aggregation is assessed using optical aggregometry, flow-cytometric P-selectin (CD62-P) expression, and soluble P-selectin levels before kidney transplantation and at the time of protocol biopsies performed at 3 and 12 months after kidney transplantation. Patients with suspected graft dysfunction undergoing indication biopsy are also included. Platelet activation markers are correlated with histopathological findings, donor-specific antibodies, metabolic parameters, and clinical outcomes. The goal is to determine whether platelet activation profiles can identify acute cellular or antibody-mediated rejection and contribute to the development of a non-invasive diagnostic tool.
This description comes directly from the study's public registry record.
Timea Blichova, MD · +421434203184 · tc@unm.sk
Patricia Kleinova, MD · +421434203184 · tc@unm.sk
Always discuss trial participation with your own doctor first.
| Transplant-Nephrology Department, University Hospital Martin | Martin, Slovakia | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07275541