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Study identifier: NCT07274046 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Burden of Tick-borne Encephalitis and Cost-effectiveness of Vaccination in the Czech Republic

Condition: Tick Borne Encephalitis (TBE)  ·  Sponsor: Charles University, Czech Republic

PhaseN/A
Planned participants209
Who can joinAll sexes, N/A to no upper limit
Healthy volunteersNo

About this study

This observational study follows children and adults who were hospitalized with tick-borne encephalitis (TBE) in the Czech Republic. The aim is to better understand how individuals recover from TBE, which symptoms may persist after the infection, and which patients may require additional support during their recovery. Participants are examined several times after hospital discharge (at 2-4 weeks, 3 months, 6 months, and 12 months) to observe changes in symptoms, functional status, and daily activities. Follow-up assessments include evaluation of common post-infection problems such as tiredness, headaches, memory or concentration difficulties, sleep issues, or limb weakness. Symptoms lasting for several months are categorized as post-encephalitic syndrome (PES). The study also assesses how TBE affects daily functioning, school and work performance, and overall quality of life using questionnaires and short functional assessments. In addition, the study includes a public-health component that estimates the broader impact of TBE in the population and evaluates the potential benefits of vaccination in preventing long-term health complications. The findings aim to support improved patient care, follow-up planning, and evidence-based public-health decision-making in the Czech Republic.

This description comes directly from the study's public registry record.

Talk to the study team

Martin Slížek, MD  ·  00420602269494  ·  martin.slizek89@gmail.com

Always discuss trial participation with your own doctor first.

Locations (4)

Ostrava University HospitalOstrava, Moravian-Silesian Region, CzechiaRecruiting
Pardubická nemocnicePardubice, Pardubice Region, CzechiaRecruiting
Bulovka University HospitalPrague, Prague, CzechiaRecruiting
České Budějovice HospitalČeské Budějovice, South Bohemian Region, CzechiaRecruiting

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Source record: clinicaltrials.gov/study/NCT07274046