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Study identifier: NCT07273838 Synced from ClinicalTrials.gov · July 29, 2026
● Recruiting

Sodium-Glucose Cotransporter-2 Inhibitor for Patients With Acute Cardiorenal Syndrome

Condition: Heart Failure · Acute Kidney Injury  ·  Sponsor: Yale University

PhasePhase 2
Planned participants130
Who can joinAll sexes, 18 Years to 85 Years
Healthy volunteersYes

About this study

The overall objective of this study is to determine whether the addition of SGLT2 inhibitors to usual care in hospitalized patients with heart failure associated acute kidney injury is safe and efficacious. Investigators will assess if SGLT2 inhibition improves a composite cardio-renal outcome (mortality, dialysis, AKI progression, decongestion metrics, heart failure symptoms). Secondary objectives of this study are to compare individual components of the composite outcome as well as changes in biomarkers of kidney injury, inflammation, repair and oxidative stress between those exposed to the SGLT2 inhibitor vs placebo.

This description comes directly from the study's public registry record.

Talk to the study team

Abinet Aklilu, MD  ·  203-931-5064  ·  abinet.aklilu@yale.edu

Francis Wilson  ·  francis.p.wilson@yale.edu

Always discuss trial participation with your own doctor first.

Locations (2)

Yale New Haven Hospital-St. Raphael CampusNew Haven, Connecticut, United StatesRecruiting
Yale New Haven HospitalNew Haven, Connecticut, United StatesRecruiting

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Source record: clinicaltrials.gov/study/NCT07273838