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Study identifier: NCT07272499 Synced from ClinicalTrials.gov · July 28, 2026
● Recruiting

Orelabrutinib Plus Lisaftoclax and Rituximab in Untreated Mantle Cell Lymphoma With High-Risk Disease

Condition: Mantle Cell Lymphoma (MCL)  ·  Sponsor: Ruijin Hospital

PhasePhase 2
Planned participants25
Who can joinAll sexes, 14 Years to no upper limit
Healthy volunteersNo

About this study

This multicenter, open-label, trial aims to evaluate the efficacy and safety of orelabrutinib plus lisaftoclax and rituximab in patients with high-risk mantle cell lymphoma (MCL). The primary objective is to assess the optimal complete response (CR) rate during the induction phase, with secondary objectives including progression-free survival (PFS), overall survival (OS), objective response rate (ORR), and safety. Exploratory analysis will investigate the correlation between tumor biomarkers and treatment efficacy.

This description comes directly from the study's public registry record.

Talk to the study team

Li Wang  ·  +862164370045  ·  wl11194@rjh.com.cn

Always discuss trial participation with your own doctor first.

Locations (1)

Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai, Shanghai Municipality, ChinaRecruiting

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Source record: clinicaltrials.gov/study/NCT07272499