Condition: Acute Myeloid Leukemia · Myelodysplastic Syndromes · Myelodysplastic/Myeloproliferative Neoplasm · Sponsor: University of Virginia
The purpose of this study is to understand the safety and estimate the efficacy of combining anti-CD3 x anti-CD33 bispecific antibody (CD33Bi) armed fresh peripheral blood mononuclear cells (CD33Bi FPBMC) for patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) where they still have detectable disease ("MRD+") after some treatment. Participants receive 4 weekly doses of CD33 FPBMC by intravenous infusion followed by 4-6 weeks of standard treatment with a hypomethylating agent (type of treatment such as decitabine or azacitidine) and possibly a drug called venetoclax. This is considered 1 cycle of study treatment and may be repeated up to 4 times during the study.
This description comes directly from the study's public registry record.
Ashley Donihee · 434-243-6377 · zwz6jm@uvahealth.org
Avani Hopkins · 434-243-8108 · AJH7JQE@uvahealth.org
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| University of Virginia | Charlottesville, Virginia, United States | Recruiting |
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Source record: clinicaltrials.gov/study/NCT07270978